2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W021787
    NH2-PEG4-CH2CH2COOH 663921-15-1 99.90%
    NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG4-CH2CH2COOH
  • HY-140757
    Azido-PEG5-NHS ester 1433996-86-1 ≥98.0%
    Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-NHS ester
  • HY-Y1096
    2-(2-Bromoethyl)-1,3-dioxolane 18742-02-4 98.76%
    2-(2-Bromoethyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs.
    2-(2-Bromoethyl)-1,3-dioxolane
  • HY-W008568
    Fmoc-amino-PEG3-CH2COOH 139338-72-0 99.81%
    Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-amino-PEG3-CH2COOH
  • HY-W005056
    Boc-NH-PEG2-CH2COOH 108466-89-3 99.87%
    Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-CH2COOH
  • HY-43191
    tert-Butyl 6-bromohexanoate 65868-63-5 99.72%
    tert-Butyl 6-bromohexanoate is a PROTAC linker. tert-Butyl 6-bromohexanoate can be used to design PROTAC, such as PROTAC ERK5 degrader-1 (HY-176528).
    tert-Butyl 6-bromohexanoate
  • HY-W013458
    Bis(2-bromoethyl) ether 5414-19-7 99.91%
    Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis(2-bromoethyl) ether
  • HY-140762
    Azido-PEG24-NHS ester 2375600-46-5
    Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG24-NHS ester
  • HY-126957
    Biotin-PEG2-azide 1910803-72-3
    Biotin-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG2-azide
  • HY-W010764
    Biotin-PEG2-Mal 305372-39-8 99.64%
    Biotin-PEG2-Mal is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG2-Mal
  • HY-108369
    Azido-PEG1-CH2CO2H 79598-48-4 99.58%
    Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition.
    Azido-PEG1-CH2CO2H
  • HY-133400
    endo-BCN-PEG3-mal 2141976-33-0 99.61%
    endo-BCN-PEG3-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG3-mal is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG3-mal
  • HY-130907
    Fmoc-N-PEG24-acid 2170484-59-8 99.91%
    Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG24-acid
  • HY-W074901
    tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate 381722-48-1 99.92%
    tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate
  • HY-130324
    Azido-PEG7-amine 1333154-77-0 99.93%
    Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-amine
  • HY-140468
    Boc-N-amido-PEG3-acid 1347750-75-7 99.69%
    Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-N-amido-PEG3-acid
  • HY-128833
    Bis-NH2-PEG2 929-59-9 99.82%
    Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-NH2-PEG2
  • HY-140915
    Biotin-PEG4-Picolyl azide 2222687-71-8 98.66%
    Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Picolyl azide
  • HY-140820
    Bromo-PEG3-azide 1446282-43-4 98.20%
    Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG3-azide
  • HY-W008296
    NH2-C6-NH-Boc 51857-17-1 99.77%
    NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.
    NH2-C6-NH-Boc
PROTAC Linkers Isoform Comparison

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